Bundle of His cell to Purkinje myocyte communication

Across TCGA patient cohorts, RNA activity of the Bundle of His cell to Purkinje myocyte communication pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSP, SH3RF2, and PERP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bundle of His cell to Purkinje myocyte communication activity versus DSP in LSCC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DSP →	+1.551	+0.857	<.001	<.001	3	7
OV	SH3RF2 →	+0.949	+0.632	.002	.001	3	7
LSCC	PERP →	+1.337	+0.797	<.001	<.001	3	6
OV	PKP2 →	+1.235	+0.602	<.001	.001	3	6
HNSC	LILRB1 →	-0.975	-1.083	<.001	<.001	3	6
COAD	MS4A6A →	-0.486	-0.265	.004	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086069 vs DSP — LSCC

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