Bundle of His cell to Purkinje myocyte communication

Across TCGA cell cohorts, RNA activity of the Bundle of His cell to Purkinje myocyte communication pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SENP6, FBXO8, and SLC6A14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SENP6 grouped by Bundle of His cell to Purkinje myocyte communication-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SENP6 →	-0.414	-1.287	.004	.001	3	5
LUNG_NSCLC_LUSC	FBXO8 →	-0.266	-0.332	.005	.006	3	4
PANCREAS	SLC6A14 →	-0.212	-0.566	.001	<.001	3	3
STOMACH	STX17 →	+0.171	+0.470	.009	.003	3	3
STOMACH	WDTC1 →	+0.211	+0.514	<.001	<.001	3	3
LUNG_NSCLC_LUAD	ITGB1 →	+0.142	+0.606	.009	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SENP6 by Bundle of His cell to Purkinje myocyte communication activity — SKIN

Explore this box plot interactively →