Purkinje myocyte to ventricular cardiac muscle cell communication

Across TCGA patient cohorts, RNA activity of the Purkinje myocyte to ventricular cardiac muscle cell communication pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FNDC3A, PRPH2, and PADI2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purkinje myocyte to ventricular cardiac muscle cell communication activity versus FNDC3A in LSCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FNDC3A →	+0.279	+0.275	.001	.004	3	3
GBM	PRPH2 →	+0.448	+0.847	<.001	.001	3	3
HNSC	PADI2 →	+1.470	+1.280	<.001	<.001	3	3
GBM	PPP1R1A →	+0.517	+0.792	.001	<.001	3	3
GBM	ERMN →	+2.399	+1.106	<.001	<.001	3	3
GBM	PRKACB →	+0.400	+0.759	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086068 vs FNDC3A — LSCC

Explore this scatter interactively →