Purkinje myocyte to ventricular cardiac muscle cell communication

Across TCGA cell cohorts, RNA activity of the Purkinje myocyte to ventricular cardiac muscle cell communication pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC22A1, TSPAN14, and ANXA11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC22A1 grouped by Purkinje myocyte to ventricular cardiac muscle cell communication-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLC22A1 →	+0.375	+0.836	<.001	.006	3	4
LUNG_NSCLC_LUAD	TSPAN14 →	+1.297	+0.810	<.001	<.001	3	3
LUNG_NSCLC_LUAD	ANXA11 →	+0.735	+0.704	<.001	.003	3	3
LUNG_NSCLC_LUAD	TTC7A →	+0.971	+0.665	.001	.005	3	3
CNS	WNT5B →	+1.728	+0.670	.005	.009	3	3
CNS	PTPN14 →	+0.894	+0.659	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC22A1 by Purkinje myocyte to ventricular cardiac muscle cell communication activity — SOFT_TISSUE

Explore this box plot interactively →