Atrial cardiac muscle cell to AV node cell communication

Across TCGA patient cohorts, RNA activity of the Atrial cardiac muscle cell to AV node cell communication pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SGCD, TRIP13, and XRCC1_S241, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrial cardiac muscle cell to AV node cell communication activity versus SGCD in UCEC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SGCD →	+0.539	+0.075	<.001	<.001	3	6
GBM	TRIP13 →	-0.377	-0.057	.003	.004	3	6
LUAD	XRCC1_S241 →	-0.946	-0.073	.003	.001	3	6
LSCC	DCAF13 →	-0.334	-0.065	<.001	<.001	3	6
LSCC	MRTO4 →	-0.357	-0.062	<.001	<.001	3	6
PDAC	ADARB1 →	+0.297	+0.050	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086066 vs SGCD — UCEC

Explore this scatter interactively →