Atrial cardiac muscle cell to AV node cell communication

Across TCGA patient cohorts, RNA activity of the Atrial cardiac muscle cell to AV node cell communication pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMP3, CNRIP1, and LMOD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrial cardiac muscle cell to AV node cell communication activity versus TIMP3 in OV (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TIMP3 →	+1.379	+0.649	<.001	<.001	3	8
OV	CNRIP1 →	+0.930	+0.877	<.001	<.001	3	8
UCEC	LMOD1 →	+1.518	+1.095	.001	<.001	3	8
BRCA	GAS1 →	+1.144	+0.871	<.001	<.001	3	8
UCEC	DACT3 →	+0.891	+0.887	<.001	<.001	3	8
OV	TMEM119 →	+1.257	+0.676	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086066 vs TIMP3 — OV

Explore this scatter interactively →