Atrial cardiac muscle cell to AV node cell communication

Across TCGA cell cohorts, RNA activity of the Atrial cardiac muscle cell to AV node cell communication pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NLGN3, NIT1, and ZNF821, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NLGN3 grouped by Atrial cardiac muscle cell to AV node cell communication-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NLGN3 →	+0.512	+1.004	.004	<.001	3	5
PANCREAS	NIT1 →	+0.741	+1.277	<.001	<.001	3	5
PANCREAS	ZNF821 →	+0.819	+1.019	.001	.002	3	4
CNS	NISCH →	+0.537	+0.710	<.001	.002	3	4
CNS	CEP68 →	+0.451	+0.950	<.001	.001	3	4
CNS	KHDRBS1 →	+0.349	+0.747	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NLGN3 by Atrial cardiac muscle cell to AV node cell communication activity — PANCREAS

Explore this box plot interactively →