Cell communication involved in cardiac conduction

Across TCGA patient cohorts, RNA activity of the Cell communication involved in cardiac conduction pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD4, TNFAIP8L2, and LAIR1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell communication involved in cardiac conduction activity versus CD4 in CHOL (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	CD4 →	-1.263	-0.049	.002	.004	2	18
CHOL	TNFAIP8L2 →	-1.348	-0.053	.003	.003	2	18
THYM	LAIR1 →	-1.039	-0.019	<.001	<.001	3	17
SARC	APOE →	-1.741	-0.027	<.001	<.001	3	17
CHOL	SELPLG →	-1.354	-0.044	.004	.009	1	18
PAAD	TYROBP →	-0.988	-0.027	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086065 vs CD4 — CHOL

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