Cell communication involved in cardiac conduction

Across TCGA patient cohorts, RNA activity of the Cell communication involved in cardiac conduction pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DSG2, DOCK11, and PKP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell communication involved in cardiac conduction activity versus DSG2 in OV (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DSG2 →	+0.471	+0.040	<.001	<.001	3	7
OV	DOCK11 →	-0.504	-0.042	<.001	<.001	3	5
LUAD	PKP2 →	+0.812	+0.037	<.001	<.001	3	5
COAD	QKI →	-0.291	-0.041	<.001	<.001	3	5
UCEC	STXBP5 →	+0.326	+0.050	<.001	.002	3	5
BRCA	CAMK2D →	+0.264	+0.026	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086065 vs DSG2 — OV

Explore this scatter interactively →