Cell communication involved in cardiac conduction

Across TCGA patient cohorts, RNA activity of the Cell communication involved in cardiac conduction pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRYAB, SGIP1, and KRT6A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell communication involved in cardiac conduction activity versus CRYAB in LSCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CRYAB →	+1.226	+0.323	<.001	.002	3	5
CCRCC	SGIP1 →	+0.914	+0.533	<.001	.006	3	5
LSCC	KRT6A →	+2.125	+0.256	<.001	.005	3	5
CCRCC	RFTN2 →	+0.563	+0.647	<.001	<.001	3	4
CCRCC	LMOD1 →	+0.985	+0.542	<.001	.003	3	4
LSCC	AMOTL1 →	+0.781	+0.276	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086065 vs CRYAB — LSCC

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