Cell communication by electrical coupling involved in cardiac conduction

Across TCGA patient cohorts, RNA activity of the Cell communication by electrical coupling involved in cardiac conduction pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CES1, PDZD2_S2341, and SYTL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell communication by electrical coupling involved in cardiac conduction activity versus CES1 in COAD (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CES1 →	-0.692	-0.041	<.001	<.001	3	5
LUAD	PDZD2_S2341 →	+0.769	+0.052	<.001	<.001	2	5
UCEC	SYTL2 →	+0.473	+0.062	.001	<.001	3	4
BRCA	CAMK2D →	+0.386	+0.054	<.001	<.001	2	5
LSCC	DHFR →	-0.465	-0.048	.001	<.001	3	4
GBM	SLC12A4 →	+0.232	+0.044	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086064 vs CES1 — COAD

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