Cell communication by electrical coupling involved in cardiac conduction

Across TCGA patient cohorts, RNA activity of the Cell communication by electrical coupling involved in cardiac conduction pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPC25, RACGAP1, and CENPE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell communication by electrical coupling involved in cardiac conduction activity versus SPC25 in UCEC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPC25 →	-0.870	-0.195	<.001	<.001	3	5
UCEC	RACGAP1 →	-0.787	-0.169	<.001	<.001	3	5
UCEC	CENPE →	-0.986	-0.165	<.001	.001	3	5
UCEC	CDKN3 →	-0.861	-0.176	.002	.001	3	4
GBM	MYBL2 →	-1.103	-0.368	.002	.001	2	5
GBM	RP2 →	-0.323	-0.357	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086064 vs SPC25 — UCEC

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