Cell communication by electrical coupling involved in cardiac conduction

Across TCGA cell cohorts, RNA activity of the Cell communication by electrical coupling involved in cardiac conduction pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKP2, CACNA1C, and ATP1A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PKP2 grouped by Cell communication by electrical coupling involved in cardiac conduction-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PKP2 →	-0.309	-0.349	.003	.001	3	5
CNS	CACNA1C →	-0.279	-0.682	.001	.008	3	5
BREAST	ATP1A1 →	-0.293	-0.443	<.001	.002	3	5
LIVER	CALM2 →	-0.372	-0.320	.007	.003	2	6
SOFT_TISSUE	HTR6 →	-0.205	-0.385	.008	<.001	3	5
KIDNEY	GRAP2 →	-0.195	-0.908	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PKP2 by Cell communication by electrical coupling involved in cardiac conduction activity — SOFT_TISSUE

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