Cell communication by electrical coupling involved in cardiac conduction

Across TCGA cell cohorts, RNA activity of the Cell communication by electrical coupling involved in cardiac conduction pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAD1, VASH1, and PKP2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell communication by electrical coupling involved in cardiac conduction activity versus LAD1 in URINARY_TRACT (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	LAD1 →	+5.840	+0.537	<.001	.006	3	8
STOMACH	VASH1 →	-1.843	-0.661	<.001	<.001	3	8
OVARY	PKP2 →	+2.595	+0.390	.007	.006	2	8
LARGE_INTESTINE	FXYD3 →	+4.086	+0.452	<.001	<.001	3	7
OVARY	RBM47 →	+2.498	+0.379	.002	.001	3	7
URINARY_TRACT	DLG4 →	-3.342	-0.438	<.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086064 vs LAD1 — URINARY_TRACT

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