Membrane depolarization during SA node cell action potential

Across TCGA patient cohorts, RNA activity of the Membrane depolarization during SA node cell action potential pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SETD7, ANK2, and STXBP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane depolarization during SA node cell action potential activity versus SETD7 in PDAC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SETD7 →	+0.272	+0.216	<.001	.004	3	6
HNSC	ANK2 →	+0.419	+0.869	<.001	<.001	3	6
PDAC	STXBP1 →	+0.314	+0.163	<.001	.001	3	6
HNSC	PURA →	+0.247	+0.798	<.001	<.001	3	6
OV	ANKRD22 →	-0.561	-0.075	.001	.008	3	5
HNSC	MTFR1L_S238 →	+0.299	+0.807	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086046 vs SETD7 — PDAC

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