Membrane depolarization during SA node cell action potential

Across TCGA patient cohorts, RNA activity of the Membrane depolarization during SA node cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANK2, ATP1A2, and RRM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane depolarization during SA node cell action potential activity versus ANK2 in CCRCC (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ANK2 →	+0.888	+0.524	<.001	<.001	3	7
GBM	ATP1A2 →	+1.334	+0.806	<.001	<.001	3	6
LSCC	RRM1 →	-0.486	-0.619	.004	.003	3	6
PDAC	CCL19 →	+1.520	+0.422	<.001	.002	3	6
LUAD	ACKR1 →	+0.958	+0.713	<.001	<.001	3	6
LSCC	SPNS3 →	+0.461	+0.923	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086046 vs ANK2 — CCRCC

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