Membrane depolarization during SA node cell action potential

Across TCGA cell cohorts, RNA activity of the Membrane depolarization during SA node cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRPF19, OSBPL7, and CD55, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRPF19 grouped by Membrane depolarization during SA node cell action potential-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PRPF19 →	-0.552	-1.380	.003	<.001	3	5
STOMACH	OSBPL7 →	+2.368	+0.808	.001	.004	3	5
LUNG_NSCLC_LUSC	CD55 →	+1.729	+1.527	.003	<.001	3	4
LUNG_NSCLC_LUSC	FAM136A →	-1.156	-1.573	.002	<.001	3	4
LUNG_NSCLC_LUAD	CANX →	+0.548	+0.895	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	JMY →	+0.860	+1.197	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRPF19 by Membrane depolarization during SA node cell action potential activity — BLOOD_Myeloma

Explore this box plot interactively →