Membrane depolarization during SA node cell action potential

Across TCGA cell cohorts, RNA activity of the Membrane depolarization during SA node cell action potential pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POU2F2, SPTB, and CLVS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POU2F2 grouped by Membrane depolarization during SA node cell action potential-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	POU2F2 →	-0.185	-0.784	<.001	.002	3	5
BREAST	SPTB →	+0.100	+0.977	<.001	.002	3	4
SOFT_TISSUE	CLVS2 →	+0.334	+1.542	.006	.001	3	4
BONE	ACLY →	+0.260	+0.928	<.001	.009	3	3
CNS	IL10RA →	+0.194	+0.863	.009	.004	3	3
SOFT_TISSUE	PRDM16 →	-0.262	-1.245	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POU2F2 by Membrane depolarization during SA node cell action potential activity — SKIN

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