Regulation of cardiac muscle cell membrane potential

Across TCGA patient cohorts, RNA activity of the Regulation of cardiac muscle cell membrane potential pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMA4, ADIPOQ, and FHL3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle cell membrane potential activity versus LAMA4 in OV (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LAMA4 →	+0.621	+0.099	.002	<.001	3	10
OV	ADIPOQ →	+0.879	+0.094	<.001	.001	3	9
OV	FHL3 →	+0.709	+0.102	.002	<.001	3	9
OV	OLFML3 →	+0.850	+0.084	<.001	.001	3	9
BRCA	TLN1_S1641 →	+0.846	+0.076	<.001	<.001	3	9
UCEC	MSRB3 →	+0.696	+0.086	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086036 vs LAMA4 — OV

Explore this scatter interactively →