Regulation of cardiac muscle cell membrane potential

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle cell membrane potential pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRMT1L, MEIS2, and SERF1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRMT1L grouped by Regulation of cardiac muscle cell membrane potential-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TRMT1L →	-0.927	-0.193	.005	.002	3	4
CNS	MEIS2 →	-1.338	-0.984	.009	.006	3	4
URINARY_TRACT	SERF1B →	-1.080	-2.002	.002	<.001	3	4
LUNG_NSCLC_LUSC	SLC25A22 →	-0.951	-0.380	<.001	.007	3	4
LIVER	GAPDH →	-1.036	-0.334	<.001	.002	3	4
LIVER	TAOK1 →	-0.766	-0.227	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRMT1L by Regulation of cardiac muscle cell membrane potential activity — BLOOD_Myeloma

Explore this box plot interactively →