Regulation of cardiac muscle cell membrane potential

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle cell membrane potential pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX39B, CHEK1, and NHP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDX39B grouped by Regulation of cardiac muscle cell membrane potential-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DDX39B →	+0.487	+0.307	.003	<.001	3	6
LIVER	CHEK1 →	+0.393	+0.113	.001	.006	3	5
LUNG_NSCLC_LUSC	NHP2 →	+0.358	+0.141	.003	.009	3	5
BLOOD_Lymphoma	USP7 →	+0.869	+0.153	.002	.004	3	5
CNS	TARS2 →	+0.281	+0.116	.001	.001	3	5
URINARY_TRACT	PMS2P3 →	-0.173	-0.249	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDX39B by Regulation of cardiac muscle cell membrane potential activity — STOMACH

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