Regulation of cardiac muscle cell membrane potential

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle cell membrane potential pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFCAB6, TTC25, and MTCL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle cell membrane potential activity versus EFCAB6 in LUNG_NSCLC_LUAD (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	EFCAB6 →	+0.566	+0.224	<.001	.002	3	3
OESOPHAGUS	TTC25 →	+0.714	+0.239	.003	.006	3	3
OESOPHAGUS	MTCL1 →	+1.455	+0.258	.004	.002	3	3
OESOPHAGUS	SEPTIN1 →	+0.535	+0.339	.007	.002	3	3
LUNG_NSCLC_LUAD	DLX4 →	+1.081	+0.215	.007	.005	2	4
LUNG_NSCLC_LUAD	TMEM18 →	+1.042	+0.235	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086036 vs EFCAB6 — LUNG_NSCLC_LUAD

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