SA node cell to atrial cardiac muscle cell signaling

Across TCGA patient cohorts, RNA activity of the SA node cell to atrial cardiac muscle cell signaling pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANK2, ESF1_S153, and UACA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, SA node cell to atrial cardiac muscle cell signaling activity versus ANK2 in HNSC (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ANK2 →	+0.478	+0.429	<.001	<.001	3	6
PDAC	ESF1_S153 →	-0.625	-0.404	.002	.004	3	6
PDAC	UACA →	+0.364	+0.389	<.001	.004	3	6
OV	AKAP12_S627 →	+1.011	+0.053	.001	.003	3	6
GBM	SP140L_S180 →	-0.517	-0.071	<.001	.002	3	6
COAD	PARP14 →	-0.287	-0.030	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086018 vs ANK2 — HNSC

Explore this scatter interactively →