SA node cell to atrial cardiac muscle cell signaling

Across TCGA patient cohorts, RNA activity of the SA node cell to atrial cardiac muscle cell signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C7, NMD3, and CCL19, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, SA node cell to atrial cardiac muscle cell signaling activity versus C7 in LUAD (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	C7 →	+1.411	+0.832	<.001	<.001	3	6
LSCC	NMD3 →	-0.368	-0.612	.008	.001	3	6
PDAC	CCL19 →	+1.569	+0.444	<.001	.001	3	6
UCEC	ANK2 →	+1.094	+0.491	<.001	<.001	3	6
GBM	GFRA2 →	+0.938	+1.085	.001	<.001	3	6
LSCC	ABCA9 →	+0.359	+0.511	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086018 vs C7 — LUAD

Explore this scatter interactively →