Membrane depolarization during cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Membrane depolarization during cardiac muscle cell action potential pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNRIP1, FERMT2, and KANK2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane depolarization during cardiac muscle cell action potential activity versus CNRIP1 in UCEC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CNRIP1 →	+0.782	+0.054	<.001	.001	3	9
COAD	FERMT2 →	+0.750	+0.037	<.001	<.001	3	9
UCEC	KANK2 →	+0.759	+0.058	<.001	.003	3	9
UCEC	NID1 →	+0.621	+0.054	<.001	.002	3	9
BRCA	PATL1 →	-0.269	-0.032	<.001	<.001	3	9
UCEC	SORBS1 →	+1.003	+0.051	<.001	.009	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086012 vs CNRIP1 — UCEC

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