Membrane depolarization during cardiac muscle cell action potential

Across TCGA cell cohorts, RNA activity of the Membrane depolarization during cardiac muscle cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RELL2, C9orf43, and ZNF431, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RELL2 grouped by Membrane depolarization during cardiac muscle cell action potential-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RELL2 →	+1.773	+1.254	.006	.002	3	4
PANCREAS	C9orf43 →	-0.320	-0.851	<.001	.003	3	4
LUNG_NSCLC_LUSC	ZNF431 →	+1.847	+0.909	<.001	.002	3	4
BLOOD_Lymphoma	BBC3 →	+2.176	+1.784	.005	<.001	3	3
BLOOD_Lymphoma	CEPT1 →	-1.135	-1.396	.007	.007	2	4
BLOOD_Lymphoma	THAP2 →	-0.850	-1.604	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RELL2 by Membrane depolarization during cardiac muscle cell action potential activity — BLOOD_Leukemia

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