Membrane repolarization during action potential

Across TCGA patient cohorts, RNA activity of the Membrane repolarization during action potential pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMP22, LMOD1, and PRKG1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane repolarization during action potential activity versus PMP22 in BRCA (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PMP22 →	+0.845	+0.430	<.001	.002	3	7
COAD	LMOD1 →	+1.114	+0.863	.001	.001	3	7
LSCC	PRKG1 →	+0.937	+0.528	<.001	<.001	3	7
BRCA	FERMT2 →	+0.933	+0.575	<.001	<.001	3	7
OV	ACTA2 →	+1.872	+0.611	<.001	.003	3	6
BRCA	GLT8D2 →	+1.014	+0.440	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086011 vs PMP22 — BRCA

Explore this scatter interactively →