Membrane depolarization during action potential

Across TCGA patient cohorts, RNA activity of the Membrane depolarization during action potential pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PATL1, KANK2, and LARP4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane depolarization during action potential activity versus PATL1 in BRCA (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PATL1 →	-0.389	-0.046	<.001	<.001	3	9
CCRCC	KANK2 →	+0.494	+0.086	<.001	<.001	3	8
COAD	LARP4 →	-0.235	-0.025	<.001	<.001	3	8
GBM	PLCB1 →	+0.820	+0.105	<.001	<.001	3	8
PDAC	TK1 →	-0.471	-0.042	.009	.008	3	8
HNSC	FHL5 →	+0.611	+0.064	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086010 vs PATL1 — BRCA

Explore this scatter interactively →