Membrane depolarization during action potential

Across TCGA patient cohorts, RNA activity of the Membrane depolarization during action potential pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANK3, ATP13A4, and CIP2A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane depolarization during action potential activity versus ANK3 in GBM (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ANK3 →	+1.362	+1.645	<.001	<.001	3	8
LUAD	ATP13A4 →	+1.613	+0.459	.001	.004	3	6
LUAD	CIP2A →	-0.560	-0.396	.001	.003	3	5
GBM	APOD →	+1.483	+1.413	<.001	<.001	3	5
BRCA	VIPR1 →	+0.732	+0.364	.003	.005	3	4
BRCA	ACTL6A →	-0.525	-0.568	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086010 vs ANK3 — GBM

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