Membrane depolarization during action potential

Across TCGA patient cohorts, RNA activity of the Membrane depolarization during action potential pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TCOF1_T249, PLOD2, and GINS3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane depolarization during action potential activity versus TCOF1_T249 in GBM (Pearson r = -0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TCOF1_T249 →	-0.909	-2.324	.003	<.001	2	6
GBM	PLOD2 →	-1.082	-1.795	<.001	<.001	3	5
GBM	GINS3 →	-0.599	-1.455	<.001	<.001	3	4
GBM	ANK3_S867 →	+0.720	+1.532	<.001	<.001	3	4
HNSC	ANK3_S4298 →	+0.978	+0.704	<.001	<.001	3	4
HNSC	ANK3_S4342 →	+0.981	+0.722	<.001	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086010 vs TCOF1_T249 — GBM

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