Membrane depolarization during action potential

Across TCGA cell cohorts, RNA activity of the Membrane depolarization during action potential pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUSD5, FERMT2, and NKX6-1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane depolarization during action potential activity versus SUSD5 in LUNG_NSCLC_LUAD (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SUSD5 →	-1.372	-0.140	<.001	<.001	3	10
STOMACH	FERMT2 →	-3.798	-0.260	<.001	.001	3	10
OVARY	NKX6-1 →	-0.681	-0.099	.005	<.001	3	9
OVARY	RNF150 →	-0.996	-0.083	<.001	.001	3	9
BREAST	VASH1 →	-1.009	-0.150	.003	.006	3	9
LUNG_SCLC	HAPLN3 →	-2.250	-0.112	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086010 vs SUSD5 — LUNG_NSCLC_LUAD

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