Membrane repolarization

Across TCGA patient cohorts, RNA activity of the Membrane repolarization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPPP, TTC7B, and H1-0, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane repolarization activity versus TPPP in UCEC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TPPP →	+0.790	+0.039	<.001	<.001	3	7
UCEC	TTC7B →	+0.315	+0.037	<.001	<.001	3	7
LUAD	H1-0 →	+0.774	+0.040	<.001	<.001	3	7
UCEC	PEAK1 →	+0.273	+0.035	<.001	<.001	3	6
CCRCC	SEPTIN4_S325 →	+0.585	+0.037	<.001	<.001	3	6
CCRCC	SLIT3 →	+0.384	+0.032	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086009 vs TPPP — UCEC

Explore this scatter interactively →