Membrane repolarization

Across TCGA patient cohorts, RNA activity of the Membrane repolarization pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMOD1, RBMS3, and DACT3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane repolarization activity versus LMOD1 in CCRCC (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LMOD1 →	+0.801	+0.646	<.001	<.001	3	7
BRCA	RBMS3 →	+0.481	+0.500	.003	.007	3	7
CCRCC	DACT3 →	+0.855	+0.993	<.001	<.001	3	7
CCRCC	PRKG1 →	+0.756	+0.734	<.001	<.001	3	7
CCRCC	ACTA2 →	+1.226	+0.985	<.001	<.001	3	6
LSCC	IGFBP7 →	+0.678	+0.700	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086009 vs LMOD1 — CCRCC

Explore this scatter interactively →