Ventricular cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Ventricular cardiac muscle cell action potential pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CYGB, ITSN1, and PIP5K1C, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular cardiac muscle cell action potential activity versus CYGB in GBM (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CYGB →	+0.506	+0.073	<.001	<.001	3	7
LSCC	ITSN1 →	+0.314	+0.076	<.001	<.001	3	7
LSCC	PIP5K1C →	+0.247	+0.075	<.001	<.001	3	7
UCEC	PURA →	+0.271	+0.048	.002	<.001	3	7
LSCC	RCOR1_S127 →	-0.427	-0.047	<.001	<.001	3	6
LSCC	RFC1_S368 →	-0.679	-0.056	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086005 vs CYGB — GBM

Explore this scatter interactively →