Ventricular cardiac muscle cell action potential

Across TCGA cell cohorts, RNA activity of the Ventricular cardiac muscle cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALS2CL, SYTL1, and ST14, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular cardiac muscle cell action potential activity versus ALS2CL in PANCREAS (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ALS2CL →	+3.194	+1.298	<.001	.002	3	7
OVARY	SYTL1 →	+3.167	+1.200	<.001	.008	3	7
OVARY	ST14 →	+4.261	+1.399	<.001	<.001	3	7
OVARY	MAL2 →	+4.736	+1.419	<.001	.001	3	6
OVARY	SLC44A2 →	+2.746	+1.281	<.001	.001	3	6
OVARY	TMEM265 →	+2.257	+1.111	.004	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086005 vs ALS2CL — PANCREAS

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