Cardiac muscle cell action potential involved in contraction

Across TCGA patient cohorts, RNA activity of the Cardiac muscle cell action potential involved in contraction pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4_S325, SPTBN1_S257, and GUCY1A2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell action potential involved in contraction activity versus SEPTIN4_S325 in UCEC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEPTIN4_S325 →	+0.704	+0.040	<.001	.003	3	8
UCEC	SPTBN1_S257 →	+0.686	+0.056	.002	<.001	3	8
UCEC	GUCY1A2 →	+0.460	+0.036	<.001	<.001	3	8
UCEC	PURA →	+0.333	+0.055	<.001	<.001	3	8
UCEC	PRKG1 →	+0.546	+0.050	<.001	<.001	3	8
LSCC	RFC1_S368 →	-0.768	-0.046	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086002 vs SEPTIN4_S325 — UCEC

Explore this scatter interactively →