Cardiac muscle cell action potential involved in contraction

Across TCGA patient cohorts, RNA activity of the Cardiac muscle cell action potential involved in contraction pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSP, C1orf198, and SCML4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell action potential involved in contraction activity versus DSP in LSCC (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DSP →	+1.163	+0.501	<.001	.001	3	5
CCRCC	C1orf198 →	+0.686	+0.692	<.001	<.001	3	5
HNSC	SCML4 →	-0.556	-0.591	<.001	<.001	3	4
COAD	DSG4 →	+0.427	+0.914	.001	.004	3	4
BRCA	CRYAB →	+1.355	+0.903	.001	<.001	3	4
LSCC	CLCA2 →	+1.849	+0.446	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086002 vs DSP — LSCC

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