Cardiac muscle cell action potential involved in contraction

Across TCGA cell cohorts, RNA activity of the Cardiac muscle cell action potential involved in contraction pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GARS1, SH3BP4, and RIDA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GARS1 grouped by Cardiac muscle cell action potential involved in contraction-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GARS1 →	+0.979	+0.829	<.001	.003	3	5
BLOOD_Leukemia	SH3BP4 →	-1.444	-0.884	.002	<.001	3	4
KIDNEY	RIDA →	+1.043	+1.186	.007	<.001	3	4
CNS	ILF2 →	+0.481	+0.827	<.001	<.001	3	4
CNS	PTMA →	+0.408	+0.953	.004	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CTPS1 →	+1.310	+1.265	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GARS1 by Cardiac muscle cell action potential involved in contraction activity — PANCREAS

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