Cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Cardiac muscle cell action potential pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GUCY1B1, SEPTIN4_S432, and SPTBN1_S257, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell action potential activity versus GUCY1B1 in GBM (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GUCY1B1 →	+0.550	+0.082	<.001	<.001	3	7
GBM	SEPTIN4_S432 →	+0.702	+0.044	<.001	<.001	3	7
BRCA	SPTBN1_S257 →	+0.742	+0.027	<.001	<.001	3	7
PDAC	SYNPO →	+0.390	+0.030	<.001	<.001	3	7
GBM	EZH2 →	-0.864	-0.068	<.001	<.001	3	7
BRCA	GUCY1A2 →	+0.397	+0.024	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086001 vs GUCY1B1 — GBM

Explore this scatter interactively →