Cardiac muscle cell action potential

Across TCGA patient cohorts, RNA activity of the Cardiac muscle cell action potential pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKNA, PERP, and KMO, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell action potential activity versus AKNA in HNSC (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AKNA →	-0.438	-0.576	.007	.006	3	4
LSCC	PERP →	+1.234	+0.682	<.001	<.001	3	4
HNSC	KMO →	-0.634	-0.807	<.001	<.001	3	4
HNSC	MPZL2 →	+0.886	+1.075	.003	<.001	2	5
HNSC	IL21R-AS1 →	-0.429	-0.912	.005	.002	3	4
LSCC	DSP →	+1.463	+0.571	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0086001 vs AKNA — HNSC

Explore this scatter interactively →