Extracellular matrix assembly

Across TCGA patient cohorts, RNA activity of the Extracellular matrix assembly pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMOD1, MSRB3, and SORBS1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extracellular matrix assembly activity versus LMOD1 in COAD (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LMOD1 →	+1.382	+1.030	<.001	.001	3	9
BRCA	MSRB3 →	+1.175	+0.364	<.001	<.001	3	9
OV	SORBS1 →	+1.068	+0.441	<.001	<.001	3	8
COAD	MGP →	+1.938	+1.401	<.001	<.001	3	8
COAD	CNN1 →	+1.638	+0.929	<.001	.003	3	8
COAD	MYH11 →	+1.710	+0.839	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0085029 vs LMOD1 — COAD

Explore this scatter interactively →