Extracellular matrix assembly

Across TCGA cell cohorts, RNA activity of the Extracellular matrix assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCND1, ECT2L, and PSMG4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCND1 grouped by Extracellular matrix assembly-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KCND1 →	-0.765	-0.843	.005	.007	2	5
BLOOD_Leukemia	ECT2L →	+0.038	+0.903	.005	.002	3	4
BREAST	PSMG4 →	-0.673	-0.753	<.001	<.001	3	4
URINARY_TRACT	TERF2 →	+0.593	+1.493	.002	.008	3	4
URINARY_TRACT	CYB5D1 →	+1.740	+2.033	.002	<.001	3	4
KIDNEY	SH3TC1 →	-1.291	-1.211	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCND1 by Extracellular matrix assembly activity — BLOOD_Leukemia

Explore this box plot interactively →