Extracellular matrix assembly

Across TCGA cell cohorts, RNA activity of the Extracellular matrix assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGR6, PLRG1, and NME6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LGR6 grouped by Extracellular matrix assembly-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LGR6 →	-0.267	-0.190	<.001	.001	3	7
LUNG_NSCLC_LUSC	PLRG1 →	-0.317	-0.304	.001	.004	3	6
LIVER	NME6 →	-0.255	-0.243	<.001	.001	3	6
CNS	FXYD3 →	-0.176	-0.185	.001	.009	3	5
PANCREAS	PRPF19 →	-0.261	-0.205	.007	.002	3	5
KIDNEY	RALGPS1 →	+0.256	+0.392	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LGR6 by Extracellular matrix assembly activity — LUNG_SCLC

Explore this box plot interactively →