Extracellular matrix assembly

Across TCGA cell cohorts, RNA activity of the Extracellular matrix assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNL3, C3AR1, and SDCBP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Extracellular matrix assembly activity versus GNL3 in BREAST (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GNL3 →	+0.519	+0.326	.002	.006	3	5
KIDNEY	C3AR1 →	-1.099	-0.375	.006	<.001	3	4
SOFT_TISSUE	SDCBP2 →	-1.248	-0.414	.007	.006	3	4
LARGE_INTESTINE	METTL21A →	+0.862	+0.343	<.001	<.001	3	4
LARGE_INTESTINE	SMYD4 →	+0.443	+0.206	.002	.004	3	4
LIVER	UPK3BL1 →	-1.732	-0.513	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0085029 vs GNL3 — BREAST

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