Protein K6-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K6-linked ubiquitination pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF530, MARCHF2, and SERPINA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF530 grouped by Protein K6-linked ubiquitination-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZNF530 →	+0.252	+0.057	<.001	.004	3	5
UPPER_AERODIGESTIVE_TRACT	MARCHF2 →	-0.144	-0.122	.006	<.001	3	4
URINARY_TRACT	SERPINA1 →	+0.276	+0.148	.003	<.001	3	4
LUNG_NSCLC_LUSC	RPS3A →	-0.419	-0.084	.003	<.001	3	4
LIVER	PIP5K1B →	+0.206	+0.151	.008	.003	2	5
STOMACH	PTPN1 →	+0.341	+0.098	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF530 by Protein K6-linked ubiquitination activity — SKIN

Explore this box plot interactively →