Lytic vacuole organization

Across TCGA patient cohorts, RNA activity of the Lytic vacuole organization pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCA1, STAT2, and XPC-AS1, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lytic vacuole organization activity versus ABCA1 in UVM (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	ABCA1 →	+1.627	+0.035	<.001	<.001	3	33
UCS	STAT2 →	+0.929	+0.031	<.001	<.001	3	33
THYM	XPC-AS1 →	+0.908	+0.042	<.001	<.001	3	33
UCS	SNX15 →	+0.416	+0.027	<.001	<.001	3	32
KIRC	DNAH1 →	+1.062	+0.055	<.001	<.001	3	32
UVM	TEP1 →	+1.176	+0.038	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0080171 vs ABCA1 — UVM

Explore this scatter interactively →