Lytic vacuole organization

Across TCGA patient cohorts, RNA activity of the Lytic vacuole organization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL10A, RSU1, and SMC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lytic vacuole organization activity versus RPL10A in OV (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPL10A →	-0.302	-0.024	<.001	.003	3	7
GBM	RSU1 →	+0.282	+0.039	<.001	<.001	3	7
GBM	SMC2 →	-0.509	-0.034	<.001	<.001	3	7
GBM	TRIM33_S862 →	-0.678	-0.052	<.001	<.001	3	7
COAD	VAT1 →	+0.410	+0.021	<.001	<.001	3	7
GBM	CLPX →	-0.281	-0.039	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0080171 vs RPL10A — OV

Explore this scatter interactively →