Lytic vacuole organization

Across TCGA patient cohorts, RNA activity of the Lytic vacuole organization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUGT1-DT, LILRA1, and CLEC2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lytic vacuole organization activity versus SUGT1-DT in HNSC (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SUGT1-DT →	-0.388	-0.090	.001	.001	3	5
LSCC	LILRA1 →	+0.331	+0.165	<.001	<.001	3	5
LUAD	CLEC2B →	+0.550	+0.116	<.001	<.001	3	5
LSCC	FCER1G →	+0.686	+0.165	<.001	<.001	3	5
LSCC	FGR →	+0.783	+0.248	<.001	<.001	3	5
OV	HCLS1 →	+1.038	+0.172	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0080171 vs SUGT1-DT — HNSC

Explore this scatter interactively →