Lytic vacuole organization

Across TCGA cell cohorts, RNA activity of the Lytic vacuole organization pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V0C, ATP6V1A, and ATP6V0B, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP6V0C grouped by Lytic vacuole organization-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ATP6V0C →	-0.863	-2.192	.004	<.001	3	10
STOMACH	ATP6V1A →	-0.443	-0.276	.007	.001	2	8
STOMACH	ATP6V0B →	-0.419	-0.226	.001	<.001	3	5
SKIN	ATP6V1B2 →	-0.352	-0.217	.002	.001	3	4
UPPER_AERODIGESTIVE_TRACT	ABL1 →	+0.170	+0.305	<.001	.001	3	3
URINARY_TRACT	C17orf75 →	+0.215	+2.115	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP6V0C by Lytic vacuole organization activity — URINARY_TRACT

Explore this box plot interactively →