Lytic vacuole organization

Across TCGA cell cohorts, RNA activity of the Lytic vacuole organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBA, PGPEP1, and RXRA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lytic vacuole organization activity versus GBA in BLOOD_Leukemia (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GBA →	+0.867	+0.223	<.001	<.001	3	4
BLOOD_Leukemia	PGPEP1 →	+1.586	+0.214	.001	.001	3	4
BLOOD_Leukemia	RXRA →	+1.810	+0.239	.003	<.001	3	4
LUNG_SCLC	RAB2A →	+0.538	+0.157	.005	.004	3	4
LUNG_SCLC	SULT1A2 →	+0.526	+0.209	<.001	<.001	3	4
BREAST	PEX19 →	+0.876	+0.175	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0080171 vs GBA — BLOOD_Leukemia

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